Hematology

In the red bone marrow, chiefly of the axial skeleton (vertebrae, sternum, ribs, pelvis) and proximal long bones.

The pluripotent hematopoietic stem cell (HSC), which gives rise to myeloid and lymphoid progenitors.

The common myeloid progenitor and the common lymphoid progenitor.

Erythropoietin (EPO), produced primarily by the peritubular cells of the kidney in response to hypoxia.

Pronormoblast → basophilic normoblast → polychromatophilic normoblast → orthochromic normoblast → reticulocyte → mature erythrocyte.

The nucleus is extruded after the orthochromic normoblast stage, producing the reticulocyte.